Inside This Issue
The Hormonal Connection
A Smile
Endometriosis
Premenstrual Syndrome
10 Ways To Know If You Have PMS (humour)
Men's Zone
Osteoporosis Strikes Many Men
Better Definitions
Fibromyalgia Q & A
Blueberry Muffins
Calcium Facts
Inner Peace
Acupuncture
Studies of oxygen consumption and exertion show that fibromyalgia patients suffer from an inability to generate adequate energy at the cellular level. This may be influenced by a decreased availability of specific hormones such as DHEA and Growth Hormone.
DHEA
Studies conducted over the last few years have shown
that the hormone DHEA, dehydroepiandrosterone, seems to be effective for
easing fatigue and its accompanying symptoms. Individuals with
connective tissue disease and those suffering from chronic depression,
show abnormally low levels of DHEA. Recent research also identifies that
DHEA blood values are reduced in those experiencing fatigue, headaches,
and stress-related symptoms; symptoms typically present in fibromyalgia
patients as well.
DHEA is a steroid hormone which is secreted by the adrenal glands in response to a chemical stimulus from the liver. The liver hormone is called IGF-1, insulin-like growth factor-1, a byproduct of human growth hormone stimulation. Due to stress, sleep interruption, and muscle fatigue, these patients experience first a dramatic reduction in growth hormone level, then IGF-I and DHEA. With time, the blood levels and symptoms often worsens.
Since DHEA, growth hormone and IGF-1 are best known for their roles in cellular growth and repair, low levels of all three are typical in fibromyalgia patients. These patients uniformly experience a decrease in not only muscle mass, but also in physical endurance and muscle strength. Further, skeletal repair may be lowered resulting in a greater risk in the future of skeletal diseases like osteoporosis and arthritis related states. Additionally, these hormones maintain the individual's immunity. Fibromyalgia, chronic fatigue, and mixed connective tissue individuals are prone to frequent, chronic and lingering infections. They have ''colds,'' sore throats, and infections or cuts that fail to heal. Studies have been published that confirm that DHEA can stimulate the immune system and may enhance one's ability to recover from and prevent these infections. DHEA supplementation can make more IGF-1 and growth hormone available by freeing them from carrier proteins.
GROWTH HORMONE
Both in states of fibromyalgia and chronic fatigue,
there has been verification that IGF-1 (Somatomedin-C) levels are
abnormally low. Low levels of IGF-1 are representative of low levels of
growth hormone release.
Growth hormone, once released, has a profound effect on muscle tissue. Growth hormone affects not only the repair but the development of the muscle tissue itself. Dramatic new research has confirmed that growth hormone supplementation will convert type II muscle fibers into type I. Since the majority of the elderly display little energy or endurance with predominantly type II (fast twitch- no endurance) muscle fibers, rejuvenation may occur with the use of growth hormone. In a three month period of time, up to 30% of the muscle cells may convert back to type I.
The daily release of growth hormone averages about 500mcg at age 20, them declines to 200 mcg at age 40 and 25mcg at age 80.
Theories of Fibromyalgia
Standard laboratory tests of the past did not show
abnormalities in persons with fibromyalgia. Physicians are now using
tests that were formerly only used in clinical trials. These newer tests
are revealing and confirming laboratory abnormalities in persons with
fibromyalgia.
Chemical analysis of muscle tissue taken from fibromyalgia sufferers reveals that high energy phosphate may be abnormal at the spot in the muscle with the greatest tenderness when pressed.
One theory about muscle abnormalities is that muscles undergo microtrauma during normal daily activities but are repaired during the fourth stage of sleep.
In persons with fibromyalgia, restorative fourth stage sleep does not occur properly. In addition, an insulin-like growth factor, secreted by the liver upon release of growth hormone by the brain, is deficient in fibromyalgia.
So, muscle repair may be delayed or defective because the fibromyalgia sufferer does not fall into a deep sleep and the insulin like growth factor that repairs the muscle during sleep is deficient.
Other theories about the cause of fibromyalgia involve physical or emotional trauma, such as a car accident or virus, physical or sexual abuse, stress, depression, or neurochemical factors acting as triggers.
Theories about the pain of fibromyalgia focus on the perception of pain and how the message of pain travels to the brain. The pain of fibromyalgia is called alldynia, which means long-standing increase in pain perception.
The pain threshold in fibromyalgia appears to be lower. This may result from a malfunctioning transmission of the pain signal in the nerves, spinal cord, and brain, thereby magnifying the pain signal so a larger amount of pain is felt than actually exists.
These are all theories about the causes of fibromyalgia. More research needs to be conducted to determine the actual cause of fibromyalgia and to provide an understanding of how it actually works.
Return to topEndometriosis is a disease affecting women in their reproductive years. It was widely undiagnosed until recently. The name, as you've probably guessed, comes from the word endometrium. The clinical definition of endometriosis is an "abnormal growth of endometrial cells." Roughly 5.5 million women throughout North America have endometriosis. Endometriosis was at one time coined "husbanditis" because the pain that characterizes endometriosis was seen as a woman's excuse to get out of her marital duties. In the past, treating women who complained of pelvic pain ranged from tranquilizers to hysterectomies. Unfortunately, many women today are still being told that their symptoms are "in their heads" when, in fact, endometriosis is a physical disease causing real physical symptoms. What happens is that endometrial tissue forms outside the uterus and in other areas of the body. This tissue then develops into small growths, or tumors. These growths are usually benign (noncancerous) and are simply a normal type of tissue in an abnormal location.
The most common location of these endometrial growths is in the pelvic region, which affects the ovaries, the fallopian tubes, the ligaments supporting the uterus, the outer surface of the uterus, and the lining of the pelvic cavity. Forty to 50 percent of the growths are in the ovaries and fallopian tubes. Sometimes the growths are found in abdominal surgery scars, on the intestines, in the rectum, and on the bladder, vagina, cervix, and vulva. Other locations include the lung, arm, thigh, and other places outside the abdomen, but these are rare.
Since these growths are in fact pieces of uterine lining, they behave like uterine lining, responding to the hormonal cycle and trying to shed every month. These growths are blind -- they can't see where they are and think they're in the uterus. This is a huge problem during menstruation; when the growths start "shedding," there's no vagina for them to pass through, so they have nowhere to go. The result is internal bleeding, degeneration of the blood and tissue shed from the growths, inflammation of the surrounding areas, and formation of scar tissue. Depending on where these growths are located, they can rupture and spread to new areas, cause intestinal bleeding or obstruction (if they're in or near the intestines), or interfere with bladder function (if they're on or near the bladder). Infertility affects about 30 to 40 percent of endometriosis sufferers, and as the disease progresses, infertility is often inevitable.
The most common symptoms of endometriosis are pain before and during periods (much worse than normal menstrual cramps), pain during or after intercourse, and heavy or irregular bleeding. Other symptoms may include fatigue, painful bowel movements with periods, lower back pain with periods, diarrhea and/or constipation with periods, dizziness, low-grade fever, frequent infections and intestinal upset with periods. If the bladder is involved, there may be painful urination and blood in the urine with periods. Irregular menstrual cycles and heavier flows are also associated with endometriosis, but women with severe endometriosis usually continue to have regular, albeit painful, periods. Some women with endometriosis may have no symptoms at all. It's important to note that the amount of pain is not necessarily related to the extent or size of the growths. If you have at least two of these symptoms during your period or even experience them chronically, you may want to get checked out for endometriosis.
The Stages of Endometriosis
(The higher the number, the more severe the endometriosis.)
Stage I is when your endometriosis is minimal and still very thin and "filmy," hence easier to treat.
Stage II is mild endometriosis; the endometriosis is still on the thin side but is situated more deeply into your surrounding tissues.
Stage III is moderate endometriosis; your endometriosis is denser mixed with some Stage I or Stage II symptoms.
Stage IV means severe endometriosis. In this case, the endometriosis is dense and deep, a bad combination.
Diagnosis
The only way to diagnose endometriosis is with an instrument called a
laparoscope (a tubelike telescope with a light in it), used in a
procedure known as laparoscopy. The procedure is a form of minor
surgery. After a general anesthetic is administered, your abdomen is
distended (expanded) with carbon dioxide gas to make the organs easier
to see. A tiny incision is made, and a laparoscope is inserted into it.
By moving the laparoscope around, your surgeon can check for any signs
of endometrial tissue outside the uterus. Although your doctor can often
feel the endometrial growths during a pelvic exam, and your symptoms may
be telltale signs of endometriosis, no competent physician would confirm
the diagnosis without performing a laparoscopy procedure. The bottom
line is that if you've been told you have endometriosis, but you haven't
had a laparoscopy procedure done, insist that your doctor perform one,
or get a second opinion. Often, the symptoms of ovarian cancer are
identical to those of endometriosis. If you've been misdiagnosed with
endometriosis due to your doctor's failure to confirm it through a
laparoscopy, he or she may miss an early diagnosis of ovarian cancer
crucial for successful treatment.
PMS is short for premenstrual syndrome, a condition researchers suspect is a neuro-endocrinopathy. This simply means a hormone disorder originating in the brain. A woman afflicted with PMS may experience a wide variety of seemingly unrelated symptoms. For that reason, it is difficult to diagnose. There is, however, one tell-tale sign: a women with PMS usually has a cyclical pattern to her symptoms.
What Are the Symptoms of PMS?
Symptoms vary from woman to woman. They come in many combinations,
ranging in severity from mild to moderate to incapacitating. The one
most commonly linked to PMS include: depression, lethargy, fatigue,
irritability, unexplained anger, and a sense of being out of control.
Other symptoms would be migraine or other headaches, sinus problems,
edema, acne, compulsive eating, craving for sweet or salty food, joint
pain, clumsiness, back pain, eye problems, and weight gain. In addition,
we include seizures, bowel disorders, suicidal thoughts or attempts,
poor concentration, paranoia, crying, and violence. Over one hundred
symptoms have been observed, with each woman reporting her own unique
set. The key to identifying PMS is not a set of certain symptoms, but
the cyclical timing of the symptoms each month.
What Is Typical PMS Timing?
Although it is an individual matter, there are four common patterns.
A woman with PMS usually has at least five days a month free of PMS symptoms.
Who Has PMS?
Researchers claim that forty percent of women of childbearing age have
premenstrual syndrome. Problems can appear at puberty or as late as
menopause. The onset of PMS seems to follow some shock to the endocrine
system; typically menarche (first menstruation), childbirth, tubal
ligation, hysterectomy, going on or off a birth control pill, or the
advent of major life stress. It appears that PMS is hereditary and that
symptoms can become worse with age.
Is There a Cure?
First understand that the cause of PMS is unknown, but it can be
treated. A lot is up to you, the patient. The best systems for diagnosis
is to chart your own set of symptoms on a PMS symptom calendar for two
months.
We currently recommend the following: getting enough rest, exercising each day, and eliminating salt, sugar, caffeine, and alcohol. In addition, many recommend vitamin therapy, especially the B vitamins. Many PMS sufferers report transient hypoglycemia (low blood sugar). Almost all benefit from eating six small meals a day, rather than three regular meals.
Coping With PMS
For women who suspect premenstrual syndrome there are several ways of
coping that don't require a doctor's prescription:
Diet Rules
Eat six times a day: three meals a day with a mid-morning snack, a
mid-afternoon snack, and a snack before bedtime. You should not eat any
more food, however than you have previously. Now, just eat small meals.
We suggest that women who do not want to lose weight restrict daily
intake to 1,500 calories and women who need to lose weight limit
themselves to 1,000 calories a day.
Recommendations:
Dr. John Morley, director of geriatric medicine at St. Louis University, says "For years I've been telling doctors that testosterone levels decrease 10 per cent every 10 years. And that by age 40, about 40 per cent of men suffer from relative impotence. But until recently, physicians refused to acknowledge it."
Andropause questionnaire:
So how do you tell if you're suffering from the andropause?
What are options?
Men who answer "yes" to questions 1 or 7, or to any three questions, may
be suffering from the andropause and low testosterone levels. Morley
suggests that men who fail this test in all probability require
testosterone.
He uses the test strictly as a screening procedure -- appropriate
candidates are checked for bioavailable testosterone in their blood and,
if it's low, testosterone replacement therapy (TRT) is suggested.
Does the treatment have a downside?
Since its discovery, doctors have worried that the use of testosterone
might trigger enlargement of the prostate gland, or even worse, cause
prostatic cancer. In fact, experts agree that testosterone could cause
an undersized prostate gland to enlarge, but only to its normal size.
They found no supportive evidence that testosterone causes prostatic
malignancy.
Is therapy safe?
Dr. Malcolm Carruthers of London, England, has claimed for years that
it's safe to use testosterone therapy. He admits testosterone can
increase the growth of an existing cancer, but does not initiate one. In
fact, giving testosterone may even result in earlier diagnosis of cancer
as patients receiving the treatment are examined more frequently. Prior
to starting testosterone therapy, men must have a general examination,
including a rectal examination, and PSA test to rule out prostatic
cancer.
Dr. Alvaro Morales, professor of urology at Queen's University,
Kingston, Ontario, says it's prudent to prescribe Andriol, an oral form
of testosterone available in Canada, for a trial period of three months.
If Andriol has no clinical effect, it should be stopped. Should there be
improvement, it can be continued.
The big question is, how many men will opt for treatment?
Judging by the example set by women, there won't be a stampede to the
doctor's door (only 15 per cent of menopausal women use hormone
replacement therapy). Men have not insignificant obstacles to overcome.
First, if they fail the Morley test, many will simply refuse to accept
the results or will be too embarrassed to seek medical attention. Even
if they do opt for treatment, finding a physician willing to prescribe
Andriol is another matter entirely -- most physicians know little about
andropause.
Testosterone for heart, bones
But men and their doctors have to acknowledge it isn't only the libido
that can be affected by the andropause. Researchers claim that low
levels of testosterone also trigger cardiovascular disease and
osteoporosis.
Morales says: "There's no question that men lose bone as they age.
Moreover, giving testosterone can increase bone density in the lumbar
spine and hips, but to a greater degree in the spine. There's also
evidence that a low blood testosterone level is a risk factor for
cardiovascular disease, and that the use of testosterone can help
prevent heart disease."
But how does testosterone decrease the risk of myocardial
infarction?
Several years ago, Dr. Philip Sarrel, professor of gynecology at Yale
University, discovered that estrogen dilates coronary vessels while
progesterone constricts them. And he shocked doctors by presenting cases
in which he believed the use of progesterone had caused either a heart
attack or stroke.
Dr. D. Crook (a London, England cardiologist), stunned the world congress
with similar evidence. His studies show that testosterone also dilates
coronary arteries. This has interesting implications. For instance, when
heart attack patients are admitted to an emergency room they're
routinely given medication to dilate blocked coronary arteries. This
evidence suggests that, in future, patients may also receive an
intravenous injection of testosterone for the same reason.
Researchers at the congress also announced good news about the effect of
testosterone on lipid metabolism. Dr. Roland Tremblay, an
internationally respected Quebec endocrinologist, reported that
testosterone has a positive effect on blood lipids. Studies show it
lowers blood cholesterol and decreases low-density lipoproteins (the bad
cholesterol), increases high-density lipoproteins (the good cholesterol),
and decreases triglycerides.
Missed diagnosis
Another interesting message came out of Geneva -- that diagnosis of male
menopause is often missed. In fact, some physicians were prescribing
antidepressant medication such as Prozac, when what was actually needed
was long-term testosterone therapy. Future research will demonstrate how
the use of testosterone will prevent heart attacks, fractured hips and
collapsed vertebra. In the meantime, selling the benefits of
testosterone replacement therapy to men isn't easy. Unlike women, men
are more apt to see a doctor to be repaired, rather than to seek
prevention. Consequently, too many men suffer prematurely from diseases
that are largely preventable
Almost as many men as women suffer from osteoporosis according to startling new evidence from a Canadian study. Moreover, men with the degenerative bone condition often don't realize they have it, according to Dr. Wojciech Olszynski. He's director of the Saskatoon Osteoporosis Centre and taking part in the Canadian Multi Centre Osteoporosis Study (CaMos)
"We found the old concept of how many men are suffering osteoporosis is wrong. We are looking at numbers almost identical to women. We are surprised to see that 25 to 27 per cent of all men and women over age 50 have some deformities in the spine. We are talking every fourth person. There's no question that osteoporosis of the spine is coming in much higher numbers than we had expected."
"And for men, it's a significantly higher number than expected or estimated before. In American studies, they are already saying that the old concept of one in four women and one in eight men should be changed to one in four women, one in five men. We cannot find any other reason in men for fragility of the bone and susceptibility to fractures, so the only definitive diagnosis is osteoporosis," says Dr. Olszynski.
Men suffer fractures
Moreover, Dr. Olszynski says many of the spinal deformities he finds are
fractures men don't even remember.
"They are working on the farm, for example, and they have a back pain.
They consider this almost part of their life. They say-oh, I lifted
something, I had back pain for two, three weeks, then everything was
better, so I didn't bother going to the doctor," he says.
He and medical colleagues in centres across Canada are doing interviews, x-rays and ultra-sounds of almost 10 thousand Canadians for CaMos. The study began five years ago and has just been extended for another three years. The work is under the supervision of McGill University and Montreal General Hospital. Funding comes from the Medical Research Council of Canada and several drug companies.
Other centres for research include Halifax, Quebec City, Toronto, Saskatoon, Calgary, Edmonton and Vancouver. The multi-year study is providing an extensive database of information.
Hip fracture deaths
Dr. Olszynski says assessing a person's risk for getting osteoporosis
and prevention are critical health issues. Often, the disease is not
recognized until the person falls and fragile bones, often the hip,
fracture.
A lot of people die within a year of hip fractures and the
complications," he says. And according to the Osteoporosis Society of
Canada, men are more likely to die after a hip fracture than women.
Effective drug treatment
In some controlled clinical trials of men with osteoporosis, treatment
with a class of drugs called bisphosphonates increased bone density. Dr.
Olszynski has had similar results.
"I've used all the biphosphonate medications for some time, and they
work great. The main way they work is to slow down the bone turnover or
re-absorption. We just don't know why they work. The mechanism seems to
be different in men than in women," he says.
These drugs are also prescribed for women with osteoporosis. For women,
estrogen replacement hormones are sometimes prescribed as a prevention
against osteoporosis. It has been suggested that a parallel prevention
for men might be treatment with the male hormone testosterone.
Male hormone risk
"Men have a gradual drop in hormone levels as they grow older. Women
have this drastic drop in a few years with menopause and no estrogen
available. Of course this concept makes hormone replacement therapy for
men very attractive - only it doesn't work," says Dr. Olszynski.
According to the International Bone and Mineral Society, there are no
studies demonstrating the testosterone replacement reduces the risk of
bone fracture. Nor are there studies about the long-term safety of
testosterone treatments.
"It is still under study. With testosterone, there is the potential of
side effects with the prostate gland. We still debate that, and a lot of
medical people say there is potential for problems," says Dr. Olszynski.
"There is now a lot of controversy about how good hormone replacement
therapy (HRT) really is for women. And we don't know. It's a problem.
There is the extreme view that HRT may not be good for anything.
This year, the Osteoporosis Society of Canada is finishing new
guidelines for osteoporosis. So we will be delivering evidence based on
more than 60 thousand medical papers..
INGREDIENTS | INSTRUCTIONS |
80 ml (1/3 cup) margarine 180 ml (3/4 cup) sugar 5 ml (1 tsp) vanilla 2 eggs, well beaten 475 ml (2 cups) flour 10 ml (2 tsp) baking powder 2.5 ml (1/2 tsp) salt 160 ml (2/3 cup) milk 240 ml (1 cup) blueberries (can substitute any fruit or berry) |
Cream margarine well; add sugar gradually Add vanilla and eggs, beat thoroughly Sift the dry ingredients together 3 times Add alternately with the milk to the creamed mixture Stir in the blueberries* Place in greased muffin pans Bake at 200 C (400 F) for about 30 minutes * If you use apples, sprinkle top of muffins with a mixture of cinnamon and sugar |
Recommended Daily Calcium Intake | Best Dietary Sources of Calcium | |||
Infants birth - 6 months : 400mg / day 6 - 12 months : 600mg / day |
FOOD | PORTION | CALCIUM, mg | |
Nonfat instant milk | 1/4 cup | 337 | ||
Skim milk | 1 cup | 302 | ||
1% and 2% fat milk | 1 cup | 300 | ||
Whole milk | 1 cup | 290 | ||
Children 1 - 5 years : 800mg / day 6 - 11 years : 800 - 1200mg / day |
Buttermilk | 1 cup | 285 | |
Vanilla milkshake | 11 ounces | 450 | ||
Yogurt, plain | 1 cup | 415 | ||
Yogurt, fruit-flavoured | 1 cup | 345 | ||
Frozen yogurt | 4 ounces | 160 | ||
Adolescents & Young adults 11 - 24 years : 1200 - 1500mg / day |
Sour cream | 4 ounces | 130 | |
Ice cream | 1/2 cup | 88 | ||
Cheddar cheese | 1 ounce | 204 | ||
Swiss cheese | 1 ounce | 272 | ||
Parmesan | 1/4 cup | 338 | ||
Women 25 - 50 years : 1000mg / day Pregnant or lactating : 1200 - 1500mg / day Postmenopausal on estrogen : 1000mg / day Postmenopausal not on estrogen : 1500mg / day Over 65 : 1500mg / day |
Mozzarella, part-skim | 1 ounce | 183 | |
Ricotta, part-skim | 1/2 cup | 337 | ||
Cottage cheese | 1/2 cup | 63 | ||
Sardines (w/bones) | 3 ounces | 370 | ||
Oysters | 1 cup | 200 | ||
Men 25 - 50 years : 1000mg / day Over 65 : 1500mg / day |
Salmon (w/bones) | 3 ounces | 165 | |
Bok choy | 1/2 cup | 126 | ||
Kale, raw or cooked | 1 cup | 200 | ||
Broccoli, cooked | 1/2 cup | 70 | ||
Orange | 1 medium | 60 |
Acupuncture in general and electroacupuncture in particular has an excellent track record in treatment of pain. One of the leading experts in use of acupuncture in pain relief is Dr. P. Baldry after asserting categorically that acupuncture is certainly the treatment of choice for dealing with Myofascial Pain Syndrome or trigger point problems.
Dr. Baldry states: "The pain in Fibromyalgia, which would seem to be due to some as yet unidentified noxious substance in the circulation giving rise to neural hyperactivity at tender points and trigger points takes a protracted course and it is only possible by means of acupuncture to suppress this neural hyperactivity for short periods."
As is clear there are other ways, however if acupuncture is used for Fibromyalgia Baldry believes that it is necessary to repeat treatment every 2 to 3 weeks for months or even years, which he regards as unsatisfactory, "but nevertheless some patients insist that it improves the quality of their lives."
Relief from pain for weeks on end and an enhanced quality of life would seem quite a desirable objective, perhaps helping ease the pain burden while more fundamental approaches are dealing with constitutional and causative issues.
A Swiss research team in Geneva has examined the effectiveness of electro-acupuncture in treating Fibromyalgia. Seventy patients(54 women) who all met the American College of Rheumatology criteria for Fibromyalgia received either sham acupuncture ("wrong" points used) or the real thing. Various methods were used for patients to record their level of symptom activity and the amount of medication they used before and after treatment. Sleep quality, morning stiffness and pain were all monitored.
Over a three week period the electroacupuncture treatment was administered with only the doctor giving the treatment knowing whether or not the needles were being placed correctly and whether the amount and type of electrical current being passed through the needles was correct. Seven out of the eight measurements showed that only the acupuncture group and not the placebo (dummy acupuncture) group had benefits (as in all such studies a few minor improvements are always noted in the dummy or placebo group, but these were only slight).
The acupuncture group, after treatment, required far more pressure on tender points to produce pain while use of pain killing medication was virtually halved as was these patient's assessment of regional pain levels. There was also a significant increase in quality of sleep. The length of time morning stiffness was experienced only improved a small amount.
Around 25% of the treated group did not improve significantly while all the others showed a remarkable amount of improvement with some having almost complete relief of all symptoms. The duration of the improvement was noted to be "several weeks" in most patients which seems to be in line with Dr. Baldry's observation of it being necessary to repeat treatment every few weeks.
The fact that there are virtually no side effects from electroacupuncture make it attractive when compared with pain killing and/or antidepressant medication.
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Tender Times is the official publication of the Fibromyalgia Association of Sault Ste. Marie & Algoma District. We would like to encourage members to send in articles for the newsletter. |
Disclaimer: The FASSM does not promote any product or necessarily endorse the information in this newsletter. The newsletter is strictly for educational purposes only. |